Congenital diabetes mellitus and neonatal pseudodiabetes mellitus.
نویسندگان
چکیده
Diabetes mellitus is very rare in infants. Cases in recent years have been reported by Schwartzman, Crusius and Beirne (1947), by Bertoye and Stefani (1954) and by Keidan (1955), who reviewed the hitherto published cases of infantile diabetes. In Keidan's report 79 cases of infantile diabetes are mentioned, the neonatal cases attracting special interest on account of certain clinical characteristics. These cases have also been published under such varying headings as congenital diabetes (Ambard, Merklen, Schmid, Wolf and Arnovljevitch, 1925; Feldmann, 1928; Nevinny and Schretter, 1930; Schretter and Nevinny, 1930; Wylie, 1953) and neonatal diabetes mellitus (Lewis and Eisenberg, 1935). Several of the congenital cases have been but insufficiently investigated, and Lawrence and McCance (1931) by an exact clinical analysis could reject a number of these as being unproved congenital cases. In most cases falling in this group (Kitselle, 1852; Morrison, 1916; Ambard et al., 1925; Feldmann, 1928; Schretter and Nevinny, 1930; Nevinny and Schretter, 1930) the diabetic mother as well as the child died at parturition. Of proved cases of congenital diabetes there is the case reported by Guest (1949) in which diabetes was diagnosed on the ninth day after parturition, and Wylie's (1953) case discovered at the age of 2 weeks. Both of these cases resulted in permanent diabetes. The remaining cases of neonatal diabetes may be divided into two groups, the first of which may be called neonatal diabetes mellitus and into which can be put cases reported by Cuno (1910), Kochmann (1922) (these two cases are, however, doubtful) Lewis and Eisenberg (1935), Limper and Miller (1935), Devine (1938), Gans (1954), Hofman-Bang (1954) and Hickish (1956). Most of these cases of diabetes have had an abrupt course with a fatal outcome. The other group comprises diseases which differ not only from the other cases of neonatal diabetes, but also from all other instances of diabetes, because they all had a good prognosis and all were cured (Ramsey, 1926; Lawrence and McCance, 1931; Strandquist, 1932; NawrockaKanska, 1952; Arey, 1953; Keidan, 1955; and Nelson, 1954). The majority simultaneously showed a marked infectious state which, however, was not considered of primary aetiological importance. The abnormal carbohydrate metabolism has generally lasted two or three weeks only and as a rule has yielded to insulin therapy. In a few cases a cerebrally conditioned diabetic state has been suspected (Nawrocka-Kanska, 1952; Keidan, 1955). They have been described under various designations, for example, 'temporary diabetes' (Lawrence and McCance, 1931), 'transient diabetes' (Arey, 1953; Keidan, 1955). Strandquist (1932) speaks of 'infantile glycosuria simulating diabetes' and Nelson (1954) of 'diabetes mellitus syndrome in the newborn infant'. As a common name for this condition we suggest 'neonatal pseudodiabetes mellitus'.
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 32 163 شماره
صفحات -
تاریخ انتشار 1957